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Over the years, Phys­ioS­tim has estab­lished pref­er­en­tial and strong part­ner­ships with sev­eral com­pa­nies in order to sub­con­tract the fol­low­ing areas of expertise:

For­mu­la­tion Analysis

A GLP study must include a GLP exper­i­men­tal phase as well as GLP for­mu­la­tion analy­sis of the samples.

  • Devel­op­ment of a method in HPLC-​UV or LCMS/​MS in the vehicle.
  • Val­i­da­tion of a method for the assay of the test arti­cle in the appro­pri­ate vehi­cle used dur­ing Phys­ioS­tim GLP study: Specificity/​Selectivity, lin­ear­ity, accu­racy and repeata­bil­ity, sta­bil­ity of the solu­tions to be admin­is­trated, sta­bil­ity of the formulations.
  • For­mu­la­tion analysis

High through­put screening

Auto­mated patch clamp exper­i­ments: We offer val­i­dated ion chan­nel screen­ing ser­vices on the main car­diac ion chan­nels panel involved in the CiPA ini­tia­tive (hERG, Nav1.5, Cav1.2, KvLQT1/​Mink, Kir2.1, Kv4.3) and also on a wide range of other ion chan­nels screen­ing assays.

  • Auto­mated patch-​clamp plat­form enables mul­ti­ple or par­al­lel single-​cell exper­i­ments for increased throughput.
  • Flex­i­ble test­ing pro­to­cols and fast data delivery.
  • Fully val­i­dated and quality-​controlled.

High throuput mon­i­tor­ing of the phys­i­o­log­i­cal func­tion in the iPSC-​derived car­diomy­ocyte :

  • Auto­mated plat­forms for increased through­put on a vari­ety of com­mer­cially avail­able iPSC-​derived car­diomy­ocyte cell lines.
  • Flex­i­ble test­ing pro­to­cols and fast data delivery.

Gen­eral Phar­ma­col­ogy: For a com­plete safety phar­ma­col­ogy package

  • ICH S7A — Core bat­tery stud­ies (CNS – Car­dio­vas­cu­lar– Res­pi­ra­tory system)
  • ICH S7A – Fol­low up stud­ies (car­dio­vas­cu­lar — renal func­tion — gas­tro intesti­nal sys­tem — endocrine sys­tem — coagulation)

An inte­grated pre­clin­i­cal solu­tion to assess car­diotox­i­c­ity of anti­cancer drugs

Read more on the col­lab­o­ra­tion between Phys­ioS­tim, Oncode­sign and NVH Medicinal.

For more infor­ma­tion on any of these themes, please This email address is being pro­tected from spam­bots. You need JavaScript enabled to view it..