Investigation of the putative interaction between two drugs on several models at therapeutic concentrations and their consequences on the action potential prolongation
Study of the additive effects of 2 drugs on cardiac function:
- on hERG channel
- on action potentials
- on isolated Langendorff perfused heart
ex : Ziprazidone & Sotalol
Indeed, PhysioStim focused on ziprasidone, an atypical antipsychotic devoided of cardiac adverse effects in spite of its propensity to prolong the QT-interval via a hERG inhibition. Moreover, very little information is available concerning pharmacodynamic interactions between ziprasidone and other hERG channel blockers. Thus, we investigated the putative interaction between ziprasidone and d,l-sotalol on the hERG channels at therapeutic concentrations and their consequences on the action potential prolongation.
Effects of ziprasidone 10 µmol/L superfused alone (panel A) or in association with d,l-sotalol 10 µmol/L (panel B) on hERG channel inhibition.
Zip: ziprasidone; sot: d,l-sotalol. Currents were recorded at room temperature. Pulses cycling rate was 30s.