Isolated Organ Bath
Study of contractility
More and more molecules show cardiac adverse events on contractility and are usually detected at late stage. Between the early hERG screening assay and the high cost in vivo telemetry studies, the Isolated Organ Bath setup constitutes an affordable ex vivo model to detect drug-induced effects on contractility (inotropism). Preclinical determination of inotropism modification may provide valuable information for predicting toxicity in man.
Effects induced by the test article on the contractility in isolated organ bath setup. The tissue (isolated papillary muscle in this example) is fixed in the organ bath chamber and electrically stimulated. The evoked twitch force is recorded using a pressure transducer.