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Iso­lated Cardiomyocytes

guinea-​pig or human cardiomyocytes

Ven­tric­u­lar car­diomy­ocytes pro­vide you a good solu­tion to study drug effects on action poten­tial i.e. on ion chan­nels. This in vitro model can be use­ful for the eval­u­a­tion of the car­diac safety of newly devel­oped drugs accord­ing to the rec­om­men­da­tions of the Euro­pean Agency for the Eval­u­a­tion of Med­i­c­i­nal Products.

Mem­brane poten­tials are recorded with the con­ven­tional patch-​clamp tech­nique using the whole cell con­fig­u­ra­tion in the current-​clamp mode.