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Iso­lated Per­fused Heart

ECG record­ings

Between the early hERG screen­ing assay and the high cost in vivo teleme­try stud­ies, the iso­lated Lan­gen­dorff per­fused heart con­sti­tutes a use­ful afford­able inte­gra­tive ex vivo model to detect drug-​induced effects on elec­tro­car­dio­gram (includ­ing QT pro­lon­ga­tion), left ven­tric­u­lar pres­sure (inotro­pism) and coro­nary flow (vaso­con­stric­tion or vasodi­la­tion). It also allows to detect com­pounds accu­mu­la­tion in car­diac tissues.