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Action Poten­tial Recordings

The action poten­tial is the con­se­quence of the move­ments of ions through the dif­fer­ent trans­mem­brane ionic chan­nels.
There­fore, record­ing car­diac action poten­tials, using the micro­elec­trode tech­nique, allows to inves­ti­gate the reper­cus­sion of mix ion chan­nels effects on car­diac elec­tri­cal activ­ity dur­ing early car­diac safety assess­ment.
The action poten­tial assay sen­si­tiv­ity dif­fers between species and car­diac tis­sues, depend­ing on the ion chan­nels blocked by the com­pound. Among species and car­diac tis­sues, action poten­tial record­ings in female rab­bit Purk­inje fibres con­sti­tute the most sen­si­tive model to detect the effects of hERG block­ing agents on car­diac repolarization.