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Rab­bit Atria

Stan­dard Pro­to­col for GLP stud­ies:
  • six prepa­ra­tions
  • Four increas­ing cumu­la­tive con­cen­tra­tions of assay compound
  • Washout period or pos­i­tive con­trol at the end of the experiment
  • Stim­u­la­tion rates: 1 Hz
Mea­sured para­me­ters:
  • Con­duc­tion time (Ct) (ms)
  • Con­duc­tion speed (Cs) (m/​s)
  • Action Poten­tial Dura­tion at 50%, 70% and 90% of repo­lar­iza­tion (ms) = APD50, APD70, and APD90

Treated groups could be com­pared to a con­trol vehi­cle group per­formed in the same conditions.

Options: Exter­nal hypokaliemic con­di­tions, chronic pre-​treatment, incre­men­tal stim­u­la­tion rate.

Ref­er­ence com­pounds
  • fle­caïnide
  • quini­dine


figure atria