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Patch Clamp assay

Con­ven­tional man­ual Patch Clamp in HEK-​293 or CHO cells

The patch clamp tech­nique is the gold stan­dard method for assess­ing ion chan­nel func­tion­al­ity and pro­vides the most ver­sa­tile and accu­rate assess­ment of drug inter­ac­tions with ion channels.

Two main con­fig­u­ra­tions of the patch clamp tech­nique are used at Phys­ioS­tim to record ion chan­nel activ­ity: the whole cell con­fig­u­ra­tion and the per­fo­rated patch con­fig­u­ra­tion. Both meth­ods allow to study the elec­tri­cal behav­ior of the entire cell and the inter­ac­tion of a test arti­cle with a selected ion channel.

Phys­ioS­tim pro­poses a wide range of ion chan­nel assays to quickly and accu­rately pro­vide results for drug dis­cov­ery and devel­op­ment research world­wide. Assays are per­formed man­u­ally by patch clamp.