hKV1.5 assays on Human Embryonic Kidney (HEK) cells
The human KV1.5 potassium channel encodes for the ultrarapid component of the delayed rectifier potassium channel IKur. In the cardiac tissue, KV1.5 potassium channels are only expressed in atria in which it represents a major component of the cardiac repolarisation of atrial action potential. Thus KV1.5 represents a major target for the treatment of atrial fibrillation, the most common sustained arrhythmia.
|Reference compounds or positive controls
PhysioStim’s other models to study atrial drugs induced effects:
- Langendorff perfused heart : ECG recordings
- Rabbit atria: Action potential recordings and atrial conduction velocity