hKV4.3 assays on Chinese Hamster Ovary (CHO) cells
Since the KV4.3 potassium channel plays an important role in cardiac action potential repolarisation, a pharmacological reduction of the Ito current may delay the repolarisation process and may lead to a prolongation of the QT interval. Thus the KV4.3 potassium channel represent a specific target for the cardiac safety assessment
|Reference compounds or positive controls
The Kv4.3 potassium channel available at PhysioStim is expressed in CHO division-arrested cells, supplied by ChanTest.