In Vivo Cardiovascular Pharmacology

Following our over two decades experience in cardiovascular pharmacology, PhysioStim could propose under request a large panel of In vivo models both in conscious and anesthetized animals. The main goal is to investigate the target related and off-target related effects of your compounds on the cardiovascular hemodynamic and eletrocardiography. Our area of expertise covers myocardial infarction, myocardial arrhythmias, inotropism in normal and diseased heart, chronotropic events, arterial pressure, etc … .

PhysioStim has an access to the following technologies: peripheral ECG, Telemetred ECG and blood pressure, echocardiography, MRI, microcirculation, histological analysis, cardiovascular biomarkers analysis. Numerous chronic pathological deseased models could be investigated: acute ischemia reperfusion injury, heart failure following myocardial infarction, heart failure consecutive to chronic overload, myocardial arrhythmias in genetically, diseased induced (brugada, long QT syndrome, etc…) or cardiometabolic disorders (diabetic, obesity, etc, …) . Other cardiovascular exploration could be conducted in specific genetically modified animals provided by the sponsor.